Anti-androgenic activity of substituted azo- and azoxy-benzene derivatives.

نویسندگان

  • H Takahashi
  • T Ishioka
  • Y Koiso
  • M Sodeoka
  • Y Hashimoto
چکیده

Substituted phenylazo and phenylazoxy compounds were systematically prepared and their anti-androgenic activity was measured in terms of (1) the growth-inhibiting effect on an androgen-dependent cell line, SC-3, and (2) the binding affinity to nuclear androgen receptor. Generally, azo/azoxy compounds showed cell toxicity, and the growth-inhibiting effects on SC-3 cells correlated with the toxicity. However, some compounds, including 4,4'-dinitroazobenzene (25), 4,4'-dimethoxyazobenzene (33), and 2,2'-dichloroazoxybenzene (47), possessed potent anti-androgenic activity without apparent cell toxicity.

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عنوان ژورنال:
  • Biological & pharmaceutical bulletin

دوره 23 11  شماره 

صفحات  -

تاریخ انتشار 2000